In the fields of pharmacological, biotechnological and medical sciences, numerous billions of dollars are spent annually on basic and clinical research and development to better understand and promote global health. These funds support scientific, clinical and administrative salaries, chemicals, instruments and consumables, preclinical research and clinical trials, laboratory infrastructure and numerous other essential costs in relation multiple research projects undertaken across different laboratories around the globe, as science – like disease - knows no borders. Small and large scientific advances are continuously being made across areas, but how does one optimally combine and focus them to maximize their united impact on disease management. The goal of this special issue of Current Pharmaceutical Design (CPD) is to aid medical research in this endeavor by providing articles to overview current progress and future perspectives focused towards management strategies for diverse diseases. Particular challenges facing numerous laboratories are those that involve laboratory bench to clinical bedside translation in the path of successful drug discovery. Are there ways to tailor and optimize this across disorders; are there guidelines that best should be followed? Authors of this special issue were invited to generate a review article appropriate to describe technologies with potential value across diseases to provide a guiding light to identify courses of action and procedures for clinically translatable research that can both advance the success rate and shorten the timeline to support a treatment to positively impact public health goals, globally.