We assessed the effects of red imported fire ants (Solenopsis invicta; hereafter fire ant) on the foraging of hispid cotton rats (Sigmodon hispidus). We used a manipulative experiment, placing resource patches with a known amount of millet seed within areas with reduced (RIFA [-]) or ambient (RIFA [+]) numbers of fire ants. We measured giving up densities (the amount of food left within each patch) within the resource patches for 4 days to quantify the effects of fire ants on cotton rat foraging. We assessed the effects of fire ant treatment (RIFA), Day, and their interaction on cotton rat giving up densities. Giving up densities on RIFA [+] grids were nearly 2.2 times greater across all foraging days and ranged from 1.6 to 2.3 times greater from day 1 to day 4 than the RIFA [-] grids. From day 1 to day 4, mean giving up densities decreased significantly faster for the RIFA [-] than RIFA [+] treatments, 58% and 13%, respectively. Our results demonstrate that cotton rats perceive a risk of injury from fire ants, which is likely caused by interference competition, rather than direct predation. Envenomation from ants likely decrease the foraging efficiency of cotton rats resulting in more time spent foraging. Increased time spent foraging is likely stressful in terms of the opportunity for direct injury and encounters with other predators. These indirect effects may reduce an individual cotton rat's fitness and translate into lowered population abundances.