Association of Interleukin-23 Receptor Gene Single Nucleotide Polymorphisms with Ankylosing Spondylitis

Ann Clin Lab Sci. 2016 Sep;46(5):470-3.

Abstract

Objective: It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptibility to AS in the Chinese population.

Methods: A total of 157 Chinese Han patients with AS and 150 ethnically matched healthy controls were enrolled. All patients were diagnosed with AS according to the modified New York criteria. 8 single nucleotide polymorphisms (SNPs) of the IL-23R gene cluster were genotyped.

Results: None of the 8 IL-23R SNPs were found to be associated with AS in the Chinese population.

Conclusion: The association of IL-23R and AS that is seen in Caucasian patients with AS is not present in Chinese patients with AS.

Keywords: IL-23R; ankylosing spondylitis; genetics.

MeSH terms

  • Adult
  • Alleles
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Gene Frequency
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Odds Ratio
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, Interleukin / genetics*
  • Spondylitis, Ankylosing / genetics*

Substances

  • IL23R protein, human
  • Receptors, Interleukin