Abstract
Two new C-glucosyl flavonoids 6''-O-feruloylspinosin and 6''-O-feruloyl-6'''-p-hydroxybenzoylspinosin, together with five known compounds, were isolated from the seeds of Ziziphus jujube (Rhamnaceae family). Their structures were elucidated on the basis of chemical and spectroscopic evidences. Compounds 1-7 showed moderate inhibitory effects against COX-1 and COX-2 enzymes.
Keywords:
C-glucosyl flavonoids; COX inhibiting activity; Rhamnaceae; Ziziphus jujube.
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology*
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Cyclooxygenase 2 Inhibitors / chemistry
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Cyclooxygenase 2 Inhibitors / isolation & purification*
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Cyclooxygenase 2 Inhibitors / pharmacology*
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Cyclooxygenase Inhibitors / chemistry
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Cyclooxygenase Inhibitors / isolation & purification*
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Cyclooxygenase Inhibitors / pharmacology*
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology*
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Fruit / chemistry
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Molecular Structure
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Seeds / chemistry
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Ziziphus / chemistry*
Substances
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6''-O-feruloyl-6'''-p-hydroxybenzoylspinosin
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6''-O-feruloylspinosin
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Anti-Inflammatory Agents
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Flavonoids
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Glucosides