Shedding light on paraspeckle structure by super-resolution microscopy

Shi-Bin Hu; Run-Wen Yao; Ling-Ling Chen

doi:10.1083/jcb.201609008

Shedding light on paraspeckle structure by super-resolution microscopy

J Cell Biol. 2016 Sep 26;214(7):789-91. doi: 10.1083/jcb.201609008. Epub 2016 Sep 19.

Authors

Shi-Bin Hu¹, Run-Wen Yao¹, Ling-Ling Chen²

Affiliations

¹ State Key Laboratory of Molecular Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China University of Chinese Academy of Sciences, Beijing 100049, China.
² State Key Laboratory of Molecular Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China University of Chinese Academy of Sciences, Beijing 100049, China School of Life Science, ShanghaiTech University, Shanghai 200031, China linglingchen@sibcb.ac.cn.

Abstract

The nuclear body paraspeckle is built on the lncRNA Neat1 and plays important roles in gene regulation. In this issue, West et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201601071) use super-resolution structured illumination microscopy to show that paraspeckles are organized in a core-shell spheroidal structure composed of Neat1 and seven proteins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Intranuclear Inclusion Bodies / metabolism*
Intranuclear Inclusion Bodies / ultrastructure
Mammals / metabolism
Microscopy / methods*
RNA, Long Noncoding / genetics
RNA, Long Noncoding / metabolism

Substances

RNA, Long Noncoding