Abstract
Treatment of biofilm-associated infections is challenging, requiring the development of new therapeutic strategies. In this viewpoint, we discuss the use of nanoparticle-based systems as active therapeutic agents and as vehicles to transport drugs to the site of infection. These applications require understanding of the surface interactions of nanoparticles with bacteria/biofilms, an aspect that we likewise summarize.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Infections / drug therapy*
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Biocompatible Materials / chemistry
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Biofilms / drug effects*
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Biofilms / growth & development
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Drug Delivery Systems / trends
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Drug Resistance, Bacterial / drug effects*
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Humans
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Nanomedicine / trends*
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Nanostructures / administration & dosage
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Nanostructures / chemistry
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Nanostructures / therapeutic use*
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Surface Properties
Substances
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Anti-Bacterial Agents
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Biocompatible Materials