A New Case of a Complex Small Supernumerary Marker Chromosome: A Der(9)t(7;9)(p22;q22) due to a Maternal Balanced Rearrangement

Marine Manvelyan; Izabella Simonyan; Galina Hovhannisyan; Rouben Aroutiounian; Ahmed B Hamid; Thomas Liehr

doi:10.1055/s-0035-1565270

A New Case of a Complex Small Supernumerary Marker Chromosome: A Der(9)t(7;9)(p22;q22) due to a Maternal Balanced Rearrangement

J Pediatr Genet. 2015 Dec;4(4):199-200. doi: 10.1055/s-0035-1565270. Epub 2015 Oct 20.

Authors

Marine Manvelyan¹, Izabella Simonyan², Galina Hovhannisyan³, Rouben Aroutiounian³, Ahmed B Hamid⁴, Thomas Liehr⁴

Affiliations

¹ Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany; Research Center of Maternal and Child Health Protection, Yerevan, Armenia.
² Research Center of Maternal and Child Health Protection, Yerevan, Armenia.
³ Department of Genetics and Cytology, Yerevan State University, Yerevan, Armenia.
⁴ Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany.

Abstract

Complex small supernumerary marker chromosomes (sSMCs) constitute one of the smallest subsets within the patients with an sSMC. Complex sSMCs consist of chromosomal material derived from more than one chromosome, for example, the derivative der(22)t(11;22)(q23;q11.2) in Emanuel syndrome. Here, a yet unreported case of a complex sSMC formed due to a t(7;9)(p22;q22)mat is presented.

Keywords: complex small supernumerary marker chromosomes (sSMCs); genotype-phenotype correlation; partial trisomy 7; partial trisomy 9.

Publication types

Case Reports