Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease

Afr Health Sci. 2016 Jun;16(2):462-7. doi: 10.4314/ahs.v16i2.14.

Abstract

Objective: This study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls.

Method: In this study, 24 ESRD patients and 24 healthy controls were included.

Results: In our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls (5.20±0.32 vs 8.59±1.03; P<0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from healthy controls (50.18±21 vs 7.78±1.31; P<0.01). Correlation analysis showed that VDR levels were negatively correlated with CYP24A1 (r=-0.723; P<0.01).

Conclusion: VDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively correlated with CYP24A1.

Keywords: CYP24A1; Vitamin D receptor (VDR); end-stage renal disease (ESRD).

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Biomarkers / blood
  • Case-Control Studies
  • China
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hospitals, University
  • Humans
  • Kidney Failure, Chronic / blood*
  • Kidney Failure, Chronic / mortality
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Prognosis
  • Receptors, Calcitriol / analysis
  • Receptors, Calcitriol / blood*
  • Reference Values
  • Renal Dialysis / methods
  • Renal Dialysis / mortality
  • Survival Analysis
  • Vitamin D3 24-Hydroxylase / analysis
  • Vitamin D3 24-Hydroxylase / blood*

Substances

  • Biomarkers
  • Receptors, Calcitriol
  • Vitamin D3 24-Hydroxylase