Future Therapies in Burn Resuscitation

Erica I Hodgman; Madhu Subramanian; Brett D Arnoldo; Herb A Phelan; Steven E Wolf

doi:10.1016/j.ccc.2016.06.009

Future Therapies in Burn Resuscitation

Crit Care Clin. 2016 Oct;32(4):611-9. doi: 10.1016/j.ccc.2016.06.009.

Authors

Erica I Hodgman¹, Madhu Subramanian¹, Brett D Arnoldo¹, Herb A Phelan¹, Steven E Wolf²

Affiliations

¹ Division of Burns, Trauma, and Critical Care, Department of Surgery, University of Texas-Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9158, USA.
² Division of Burns, Trauma, and Critical Care, Department of Surgery, University of Texas-Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9158, USA. Electronic address: steven.wolf@utsouthwestern.edu.

PMID: 27600132
DOI: 10.1016/j.ccc.2016.06.009

Abstract

Since the 1940s, the resuscitation of burn patients has evolved with dramatic improvements in mortality. The most significant achievement remains the creation and adoption of formulae to calculate estimated fluid requirements to guide resuscitation. Modalities to attenuate the hypermetabolic phase of injury include pharmacologic agents, early enteral nutrition, and the aggressive approach of early excision of large injuries. Recent investigations into the genomic response to severe burns and the application of computer-based decision support tools will likely guide future resuscitation, with the goal of further reducing mortality and morbidity, and improving functional and quality of life outcomes.

Keywords: Burns; Fluid creep; Fluid resuscitation; Monitoring.

Publication types

Review

MeSH terms

Burns / physiopathology
Burns / therapy*
Fluid Therapy / methods*
Fluid Therapy / trends
Humans
Monitoring, Physiologic
Rehydration Solutions / administration & dosage*
Resuscitation / methods*
Resuscitation / trends

Substances

Rehydration Solutions