Color Me Infected: Painting Cellular Chromatin with a Viral Histone Mimic

Cason R King; Tanner M Tessier; Joe S Mymryk

doi:10.1016/j.tim.2016.08.005

Color Me Infected: Painting Cellular Chromatin with a Viral Histone Mimic

Trends Microbiol. 2016 Oct;24(10):774-776. doi: 10.1016/j.tim.2016.08.005. Epub 2016 Sep 1.

Authors

Cason R King¹, Tanner M Tessier¹, Joe S Mymryk²

Affiliations

¹ Department of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada.
² Department of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada; Departments of Oncology and Otolaryngology, University of Western Ontario, London, Ontario, Canada; London Regional Cancer Program and Lawson Health Research Institute, London, Ontario, Canada. Electronic address: jmymryk@uwo.ca.

PMID: 27592243
DOI: 10.1016/j.tim.2016.08.005

Abstract

Viruses manipulate cellular chromatin to create a favourable milieu for infection. In several cases, virally-encoded proteins structurally mimic cellular histones to molecularly rewire the host cell. A recent study identified a novel mechanism whereby adenovirus protein VII, a viral histone, binds and manipulates host cell chromatin to suppress inflammatory signalling.

Keywords: HMGB1; adenovirus; chromatin; inflammation; protein VII; viral mimicry.

Publication types

Comment

MeSH terms

Adenoviruses, Human / physiology*
Cell Line
Chromatin / metabolism*
HMGB1 Protein
Histones / chemistry
Histones / metabolism
Humans
Inflammation
Molecular Mimicry*
Viral Proteins / chemistry
Viral Proteins / metabolism*
Virus Replication

Substances

Chromatin
HMGB1 Protein
Histones
Viral Proteins