Familial segregation of group B streptococcal infection in a consanguineous kindred

Int J Infect Dis. 2016 Oct:51:22-24. doi: 10.1016/j.ijid.2016.08.010. Epub 2016 Aug 25.

Abstract

Two cases of neonatal group B streptococcal (GBS) infection occurring in a large consanguineous kindred are described. The observation suggests that susceptibility to isolated GBS disease in this family may have been the result of an inborn error of immunity inherited as a Mendelian autosomal recessive trait.

Keywords: GBS; Genetic; Mendelian; Neonatal; Primary immunodeficiency; Streptococcus agalactiae.

Publication types

  • Case Reports

MeSH terms

  • Antibiotic Prophylaxis
  • Antibodies, Bacterial / genetics
  • Antibodies, Bacterial / immunology
  • Consanguinity*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Streptococcal Infections / drug therapy
  • Streptococcal Infections / genetics*
  • Streptococcal Infections / immunology
  • Streptococcus agalactiae*

Substances

  • Antibodies, Bacterial