Facile approach to prepare drug-loading film from hemicelluloses and chitosan

Ying Guan; Xian-Ming Qi; Ge-Gu Chen; Feng Peng; Run-Cang Sun

doi:10.1016/j.carbpol.2016.08.008

Facile approach to prepare drug-loading film from hemicelluloses and chitosan

Carbohydr Polym. 2016 Nov 20:153:542-548. doi: 10.1016/j.carbpol.2016.08.008. Epub 2016 Aug 4.

Authors

Ying Guan¹, Xian-Ming Qi², Ge-Gu Chen², Feng Peng³, Run-Cang Sun⁴

Affiliations

¹ School of Forestry and Landscape Architecture, AnHui Agricultural University, Hefei 230036, China.
² Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.
³ Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China. Electronic address: fengpeng@bjfu.edu.cn.
⁴ Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China. Electronic address: rcsun3@bjfu.edu.cn.

PMID: 27561527
DOI: 10.1016/j.carbpol.2016.08.008

Abstract

This study introduces a facile and green route to fabricate film from bio-based polymers. The film has been prepared by the cross-linking reaction of quaternized hemicelluloses (QH) and chitosan (CHO) with epichlorohydrin (ECH) as crosslinker. It exhibits an excellently mechanical performance as a result of its high tensile strength (up to 37MPa). Importantly, the roughness of film was 2-5nm in the area of 400nm, and smooth surface with pores were presented on the film based on the results of scanning electron microscope (SEM) and atomic force microscope (AFM). Ciprofloxacin was utilized as a mode compound to investigate the loading behavior of the film, and the highest loading concentration was about 18%. The drug release was about 20% in film1 in comparison to only 15% in film3 within 48h. Furthermore, the results of a 293T cell viability assay indicated its good biocompatibility and non-toxicity.

Keywords: Biocompatibility; Chitosan; Drug-loading; Film; Qurternized hemicelluloses.

MeSH terms

Anti-Bacterial Agents / administration & dosage*
Anti-Bacterial Agents / chemistry
Bandages
Chitosan / chemistry*
Ciprofloxacin / administration & dosage*
Ciprofloxacin / chemistry
Cross-Linking Reagents / chemistry
Drug Delivery Systems / methods*
Drug Liberation
Epichlorohydrin / chemistry
Polysaccharides / chemistry*
Tensile Strength

Substances

Anti-Bacterial Agents
Cross-Linking Reagents
Polysaccharides
Epichlorohydrin
Ciprofloxacin
hemicellulose
Chitosan