SYGNALing a Red Light for Glioblastoma

Aaron N Brooks; William F Mueller; Lars M Steinmetz

doi:10.1016/j.cels.2016.08.002

SYGNALing a Red Light for Glioblastoma

Cell Syst. 2016 Aug;3(2):118-120. doi: 10.1016/j.cels.2016.08.002.

Authors

Aaron N Brooks¹, William F Mueller¹, Lars M Steinmetz²

Affiliations

¹ European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
² European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany; Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA; Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: lars.steinmetz@embl.de.

PMID: 27559923
DOI: 10.1016/j.cels.2016.08.002

Abstract

A new multiomic network inference pipeline, SYGNAL, integrates patient data with mechanistically accurate transcriptional regulatory networks to predict drug combinations with synergistic anti-proliferative effects on glioblastoma multiforme.

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MeSH terms

Brain Neoplasms / genetics
Cell Line, Tumor
Cell Proliferation
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks*
Glioblastoma / genetics*
Humans