Estrogen and Microbiota Crosstalk: Should We Pay Attention?

Karen L Chen; Zeynep Madak-Erdogan

doi:10.1016/j.tem.2016.08.001

Estrogen and Microbiota Crosstalk: Should We Pay Attention?

Trends Endocrinol Metab. 2016 Nov;27(11):752-755. doi: 10.1016/j.tem.2016.08.001. Epub 2016 Aug 20.

Authors

Karen L Chen¹, Zeynep Madak-Erdogan²

Affiliations

¹ Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USA.
² Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USA; Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address: zmadake2@illinois.edu.

PMID: 27553057
DOI: 10.1016/j.tem.2016.08.001

Abstract

Recent advances have suggested that steroid hormones such as estrogens, and gut microbiota might synergize to influence obesity, diabetes, and cancer. We discuss recent knowledge of the interactions between estrogens and gut microbiota, and new insights that might offer new approaches to influence this crosstalk and improve metabolic outcomes.

Keywords: estrogen receptor; estrogens; hormone replacement therapy; isoflavones; metabolism; microbiome.

MeSH terms

Animals
Estrogens / metabolism
Gastrointestinal Microbiome / physiology*
Hormone Replacement Therapy
Humans
Isoflavones / metabolism
Receptors, Estrogen / metabolism*

Substances

Estrogens
Isoflavones
Receptors, Estrogen