Inflammatory Cutaneous Diseases in Renal Transplant Recipients

Int J Mol Sci. 2016 Aug 19;17(8):1362. doi: 10.3390/ijms17081362.

Abstract

Kidney transplant recipients frequently suffer from skin infections and malignancies, possibly due to the effects of long-term immunosuppressive therapy. While the relationships between immunosuppression and these pathological conditions have been widely investigated, little is known about the relative incidence and characteristics of inflammatory skin diseases in this type of patient. In this study, we analyze the incidence of a number of inflammatory cutaneous diseases in a cohort of patients who underwent kidney transplantation. Although our study shows a relatively low incidence of these pathologies in transplanted patients-in agreement with the general action of immunosuppressant therapies in reducing inflammation-we scored a different efficacy of the various immunosuppressive regimens on inflammatory and autoimmune skin diseases. This information can be key for designing immunosuppressive regimens and devising accurate follow-up protocols.

Keywords: cutaneous diseases; inflammatory; kidney transplantation.

MeSH terms

  • Everolimus / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Inflammation / diagnosis
  • Inflammation / drug therapy
  • Inflammation / etiology
  • Inflammation / immunology
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Sirolimus / therapeutic use
  • Skin Diseases / diagnosis
  • Skin Diseases / drug therapy
  • Skin Diseases / etiology*
  • Skin Diseases / immunology
  • Transplant Recipients

Substances

  • Immunosuppressive Agents
  • Everolimus
  • Sirolimus