A Guardian Angel Phosphatase for Mainline Carbon Metabolism

Trends Biochem Sci. 2016 Nov;41(11):893-894. doi: 10.1016/j.tibs.2016.08.005. Epub 2016 Aug 17.

Abstract

It is increasingly clear that many metabolic enzymes mistakenly form minor but toxic side-products that must be eliminated to maintain normal fluxes. Collard et al. show that this is true of two iconic glycolytic enzymes, and that a hitherto somewhat mysterious phosphatase rescues central carbon metabolism from their mistakes.

Keywords: glycolysis; metabolite damage; metabolite repair; phosphatase; side-reaction.

Publication types

  • Comment

MeSH terms

  • Fructosediphosphates / metabolism
  • Gluconates / metabolism
  • Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / genetics
  • Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / metabolism*
  • Glycolysis / drug effects
  • Humans
  • Hydrolysis
  • Lactates / metabolism
  • Lactates / toxicity
  • Phosphoric Monoester Hydrolases / antagonists & inhibitors
  • Phosphoric Monoester Hydrolases / genetics
  • Phosphoric Monoester Hydrolases / metabolism*
  • Pyruvate Kinase / genetics
  • Pyruvate Kinase / metabolism*
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / antagonists & inhibitors
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Secondary Metabolism*
  • Sugar Acids / metabolism
  • Sugar Acids / toxicity

Substances

  • 4-phosphoerythronate
  • Fructosediphosphates
  • Gluconates
  • Lactates
  • RNA, Small Interfering
  • Saccharomyces cerevisiae Proteins
  • Sugar Acids
  • 2-phospholactic acid
  • fructose 2,6-diphosphate
  • Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)
  • Pyruvate Kinase
  • Pho13 protein, S cerevisiae
  • phosphoglycolate phosphatase
  • Phosphoric Monoester Hydrolases
  • 6-phosphogluconic acid