Evidence of H3 K27M mutations in posterior fossa ependymomas

Marco Gessi; David Capper; Felix Sahm; Kristin Huang; Andreas von Deimling; Stephan Tippelt; Gudrun Fleischhack; Daniel Scherbaum; Joachim Alfer; Björn-Ole Juhnke; Katja von Hoff; Stefan Rutkowski; Monika Warmuth-Metz; Lukas Chavez; Stefan M Pfister; Torsten Pietsch; David T W Jones; Dominik Sturm

doi:10.1007/s00401-016-1608-3

Evidence of H3 K27M mutations in posterior fossa ependymomas

Acta Neuropathol. 2016 Oct;132(4):635-7. doi: 10.1007/s00401-016-1608-3. Epub 2016 Aug 18.

Authors

Marco Gessi¹, David Capper^{2

3}, Felix Sahm^{2

3}, Kristin Huang^{2

3}, Andreas von Deimling^{2

3}, Stephan Tippelt⁴, Gudrun Fleischhack⁴, Daniel Scherbaum⁵, Joachim Alfer⁶, Björn-Ole Juhnke⁷, Katja von Hoff⁷, Stefan Rutkowski⁷, Monika Warmuth-Metz⁸, Lukas Chavez⁹, Stefan M Pfister^{9

10}, Torsten Pietsch¹, David T W Jones⁹, Dominik Sturm^{11

12}

Affiliations

¹ DGNN Brain Tumor Reference Center, Institute of Neuropathology, University of Bonn Medical Center, 53105, Bonn, Germany.
² Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, 69120, Heidelberg, Germany.
³ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
⁴ HIT-REZ Study Center, Department of Pediatric Oncology and Hematology, Pediatrics III, University Hospital Essen, 45147, Essen, Germany.
⁵ Department of Pediatric Oncology, University of Ulm, Children's Hospital, 89075, Ulm, Germany.
⁶ Institute of Pathology Kaufbeuren, 87600, Kaufbeuren, Germany.
⁷ HIT-MED Study Center, Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
⁸ Department of Neuroradiology, German Reference Center for Neuroradiology, University Hospital of Würzburg, 97080, Würzburg, Germany.
⁹ Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
¹⁰ Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany.
¹¹ Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. d.sturm@dkfz.de.
¹² Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany. d.sturm@dkfz.de.

PMID: 27539613
DOI: 10.1007/s00401-016-1608-3

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Child
Ependymoma / genetics*
Female
Histones / genetics*
Humans
Infant
Infratentorial Neoplasms / genetics*
Lysine / genetics
Methionine / genetics*
Mutation / genetics*

Substances

H3-3A protein, human
Histones
Methionine
Lysine