Expression patterns of miR-146a and miR-146b in mastitis infected dairy cattle

Mol Cell Probes. 2016 Oct;30(5):342-344. doi: 10.1016/j.mcp.2016.08.004. Epub 2016 Aug 13.

Abstract

This study reports a significant up-regulation of bta-miR-146a and bta-miR-146b expression levels in bovine mammary tissues infected with subclinical, clinical and experimental mastitis. Potential target genes are involved in multiple immunological pathways. These results suggest a regulatory function of both miRNAs for the bovine inflammatory response in mammary tissue.

Keywords: Dairy cattle; Mastitis; miR-146a; miR-146b; microRNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle / blood
  • Cattle / genetics*
  • Cattle / microbiology*
  • Dairying*
  • Female
  • Gene Expression Regulation*
  • Mammary Glands, Animal / metabolism
  • Mammary Glands, Animal / microbiology
  • Mammary Glands, Animal / pathology
  • Mastitis, Bovine / blood
  • Mastitis, Bovine / genetics*
  • Mastitis, Bovine / microbiology
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism

Substances

  • MicroRNAs