Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency

Affiliations

• ¹ Department of Pediatric Infectious Disease and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ² Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ³ Deparment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
• ⁴ Department of Women and Children Health, Division of Pediatrics, University of Padova, Padova, Italy.
• ⁵ Faculty of Medicine, Department of Pediatrics, Division of Genetics, Ege University, Izmir, Turkey.
• ⁶ Juliana Children's Hospital, Den Haag, The Netherlands.
• ⁷ Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany.
• ⁸ Faculty of Medicine, Department of Pediatrics, Division of Pediatric Immunology, Ege University, Izmir, Turkey.
• ⁹ Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address: m.vanderburg@erasmusmc.nl.