Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group

Nigel S Key; Alok A Khorana; Nigel Mackman; Owen J T McCarty; Gilbert C White; Charles W Francis; Keith R McCrae; Joseph S Palumbo; Gary E Raskob; Andrew T Chan; Anil K Sood

doi:10.1158/0008-5472.CAN-15-3100

Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group

Cancer Res. 2016 Jul 1;76(13):3671-5. doi: 10.1158/0008-5472.CAN-15-3100. Epub 2016 Jun 20.

Authors

Affiliations

¹ Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
² Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
³ Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. nigel_key@med.unc.edu.
⁴ Department of Biomedical Engineering and Cell and Development Biology, Oregon Health and Science University, Portland, Orlando.
⁵ Blood Research Institute, Blood Center of Wisconsin, Department of Medicine, Biochemistry, and Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin.
⁶ James P. Wilmot Cancer Center and Department of Medicine, University of Rochester, Rochester, New York.
⁷ Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio. Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio.
⁸ Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁹ Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
¹⁰ Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
¹¹ Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas.

PMID: 27527638
DOI: 10.1158/0008-5472.CAN-15-3100

Abstract

The risk for venous thromboembolism (VTE) is increased in cancer and particularly with chemotherapy, and it portends poorer survival among patients with cancer. However, many fundamental questions about cancer-associated VTE, or Trousseau syndrome, remain unanswered. This report summarizes the proceedings of a working group assembled by the NCI and NHLBI in August 2014 to explore the state of the science in cancer-associated VTE, identify clinically important research gaps, and develop consensus on priorities for future research. Representing a convergence of research priorities between the two NIH Institutes, the workshop addressed epidemiologic, basic science, clinical, and translational issues in cancer-associated VTE. Cancer Res; 76(13); 3671-5. ©2016 AACR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomedical Research / methods*
Humans
National Cancer Institute (U.S.)
National Heart, Lung, and Blood Institute (U.S.)*
Neoplasms / complications*
Research Report*
Thrombosis / diagnosis
Thrombosis / etiology*
Thrombosis / therapy*
United States