Stress-Induced Stroke and Stomach Cancer: Sex Differences in Oxygen Saturation

Adv Exp Med Biol. 2016:923:135-140. doi: 10.1007/978-3-319-38810-6_18.

Abstract

Sex differences in stress-related diseases such as stroke and stomach cancer are well established, but the mechanisms underlying this phenomenon remain unknown. Despite the fact that sexual hormones play an important role in the high resistance of females to harmful effects of stress compared with males, the regulation of oxygenation status can be a potential factor, which might explain sex differences in stress-induced cerebrovascular catastrophes in newborn rats and in mutagens activation in adult rats with stomach cancer.

Keywords: Haemorrhagic stroke; Oxygen saturation; Sex differences.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Cell Hypoxia
  • Cerebral Cortex / metabolism*
  • Cerebral Cortex / pathology
  • Disease Models, Animal
  • Female
  • Gastric Mucosa / metabolism*
  • Gastric Mucosa / pathology
  • Housing, Animal
  • Male
  • Nitrosamines
  • Noise / adverse effects
  • Oxygen / blood
  • Oxygen / metabolism*
  • Rats
  • Sex Factors
  • Stomach Neoplasms / etiology*
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / metabolism
  • Stomach Neoplasms / pathology
  • Stress, Psychological / complications*
  • Stress, Psychological / metabolism
  • Stroke / etiology*
  • Stroke / metabolism
  • Stroke / pathology
  • Tumor Hypoxia

Substances

  • Nitrosamines
  • Oxygen