[Radiotherapy for brain metastases]

Cancer Radiother. 2016 Sep:20 Suppl:S80-7. doi: 10.1016/j.canrad.2016.07.041. Epub 2016 Aug 11.
[Article in French]

Abstract

Radiotherapy for brain metastases has become more multifaceted. Indeed, with the improvement of the patient's life expectancy, side effects must be undeniably avoided and the retreatments or multiple treatments are common. The cognitive side effects should be warned and the most modern techniques of radiation therapy are used regularly to reach this goal. The new classifications of patients with brain metastases help guiding treatment more appropriately. Stereotactic radiotherapy has supplanted whole brain radiation therapy both for patients with metastases in place and for those who underwent surgery. Hippocampus protection is possible with intensity-modulated radiotherapy. Its relevance in terms of cognitive functioning should be more clearly demonstrated but the requirement, for using it, is increasingly strong. While addressing patients in palliative phase, the treatment of brain metastases is one of the localisations where technical thinking is the most challenging.

Keywords: Brain metastasis; Cognition; Hippocampe; Hippocampus; IMRT; Métastases cérébrales; RCMI; Stereotactic; Stéréotaxie.

Publication types

  • Practice Guideline

MeSH terms

  • Age Factors
  • Brain / radiation effects
  • Brain Neoplasms / radiotherapy*
  • Brain Neoplasms / secondary*
  • Cognition Disorders / etiology
  • Cognition Disorders / prevention & control
  • Combined Modality Therapy
  • Cranial Irradiation / adverse effects
  • Cranial Irradiation / methods*
  • Cranial Irradiation / standards
  • Dose Fractionation, Radiation
  • Humans
  • Organs at Risk
  • Radiation Injuries / prevention & control
  • Radiosurgery / adverse effects
  • Radiosurgery / methods
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy, Intensity-Modulated / adverse effects
  • Radiotherapy, Intensity-Modulated / methods