Theoretical principles for biology: Organization

Prog Biophys Mol Biol. 2016 Oct;122(1):24-35. doi: 10.1016/j.pbiomolbio.2016.07.005. Epub 2016 Aug 10.

Abstract

In the search of a theory of biological organisms, we propose to adopt organization as a theoretical principle. Organization constitutes an overarching hypothesis that frames the intelligibility of biological objects, by characterizing their relevant aspects. After a succinct historical survey on the understanding of organization in the organicist tradition, we offer a specific characterization in terms of closure of constraints. We then discuss some implications of the adoption of organization as a principle and, in particular, we focus on how it fosters an original approach to biological stability, as well as and its interplay with variation.

Keywords: Closure; Constraints; Organicism; Organization; Stability; Theoretical principle.

Publication types

  • Review

MeSH terms

  • Animals
  • Biology / methods*
  • Humans
  • Models, Biological