Genetics of Bariatric Surgery Outcomes

Olivier F Noel; Christopher D Still; Glenn S Gerhard

doi:10.1016/j.ecl.2016.04.011

Genetics of Bariatric Surgery Outcomes

Endocrinol Metab Clin North Am. 2016 Sep;45(3):623-32. doi: 10.1016/j.ecl.2016.04.011.

Authors

Olivier F Noel¹, Christopher D Still², Glenn S Gerhard³

Affiliations

¹ Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA; Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA; DNAsimple, Philadelphia, PA, USA.
² Department of Gastroenterology and Nutrition, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17822, USA.
³ Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, 960 Medical Education and Research Building (MERB), 3500 North Broad Street, Philadelphia, PA 19140, USA. Electronic address: gsgerhard@Temple.edu.

PMID: 27519134
DOI: 10.1016/j.ecl.2016.04.011

Abstract

Outcomes after bariatric surgery can vary widely and seem to have a significant genetic component. Only a small number of candidate gene and genome-wide association studies have analyzed bariatric surgery outcomes. The role of bile acids in mediating the beneficial effects of bariatric surgery implicate genes regulated by the farnesoid X receptor transcription factor.

Keywords: Bariatric surgery; Genetics; NAFLD; Type 2 diabetes mellitus; Weight loss.

Publication types

Review

MeSH terms

Bariatric Surgery*
Bile Acids and Salts
Genome-Wide Association Study
Humans
Receptors, Cytoplasmic and Nuclear / genetics
Treatment Outcome
Weight Loss / genetics*

Substances

Bile Acids and Salts
Receptors, Cytoplasmic and Nuclear
farnesoid X-activated receptor

Grants and funding

R01 DK088231/DK/NIDDK NIH HHS/United States