Abstract
The investigation was conducted in 20 children, operated on for abdominal oncological diseases in a 2010-2015 yrs period, using various methods of analgesia. While application of a constant infusion of high doses of phentanyl--1-4 MKr/(kg x h) in perioperative period the occurrence of the opiate-induced hyperalgesia is possible with the accompanied morphological changes in intestinal wall; in anesthesia of a transverse abdominal muscle (a TAP-blockade) and combined spinal epidural analgesia such changes were not observed.
MeSH terms
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Abdominal Muscles / drug effects*
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Abdominal Muscles / innervation
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Abdominal Muscles / surgery
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Abdominal Neoplasms / pathology
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Abdominal Neoplasms / surgery
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Adolescent
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Analgesia, Epidural / methods*
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Analgesics, Opioid / administration & dosage
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Analgesics, Opioid / adverse effects*
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Child
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Child, Preschool
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Female
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Fentanyl / administration & dosage
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Fentanyl / adverse effects*
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Humans
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Hyperalgesia / etiology
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Hyperalgesia / pathology
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Hyperalgesia / prevention & control*
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Infant
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Infusions, Parenteral
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Male
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Pain, Postoperative / physiopathology
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Pain, Postoperative / prevention & control
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Postoperative Period
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Retrospective Studies
Substances
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Analgesics, Opioid
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Fentanyl