Vascular density, angiogenesis and pro-angiogenic factors in uterine fibroids

Folia Med Cracov. 2016;56(1):27-32.

Abstract

Angiogenesis is a process of development of new vessels from the preexisting vascular network of a host. This is process which is seen in many physiological situations but it accompanies also a development of different lesions, i.e. neoplasms. Uterine fibroids are one of the most frequent lesions which affect human internal female genital tracts. Authors briefly review most important pro-angiogenic factors, based on their own observation as well as reviewing current literature. They pay much attention to vascular density which is significantly changed in the uterine tumors.

Keywords: angiogenesis; uterine fibroids; vascular density.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inducing Agents / metabolism*
  • Female
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Leiomyoma / etiology*
  • Myometrium / metabolism*
  • Neovascularization, Pathologic*
  • Uterine Neoplasms / etiology*
  • Uterus / blood supply*
  • Vascular Endothelial Growth Factors / metabolism

Substances

  • Angiogenesis Inducing Agents
  • Intercellular Signaling Peptides and Proteins
  • Vascular Endothelial Growth Factors