Abstract
Many exceptional labdane-type diterpenoids have been exclusively found in liverworts, which serve as taxonomic molecules or play important ecological roles in interactions among organisms. Three unprecedented labdane-type diterpenoids hapmnioides A (1), B (2), and C (3) formed through cascade rearrangement from the Chinese liverwort Haplomitrium mnioides are reported. Their structures were established by comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction, and their anti-inflammatory activities were also preliminarily tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Cell Line
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China
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Hepatophyta / chemistry*
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Humans
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Interleukin-6 / antagonists & inhibitors*
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Interleukin-6 / metabolism
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Mice
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Models, Molecular
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Molecular Conformation
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NF-kappa B / antagonists & inhibitors*
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NF-kappa B / metabolism
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Signal Transduction / drug effects*
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Stereoisomerism
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Diterpenes
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Interleukin-6
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NF-kappa B