Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

Suguna Lakshmi Madurai; Stella Winnarasi Joseph; Asit Baran Mandal; John Tsibouklis; Boreddy Sr Reddy

doi:10.1007/s11671-010-9749-0

Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

Nanoscale Res Lett. 2011 Dec;6(1):15. doi: 10.1007/s11671-010-9749-0. Epub 2010 Aug 27.

Authors

Suguna Lakshmi Madurai¹, Stella Winnarasi Joseph¹, Asit Baran Mandal¹, John Tsibouklis², Boreddy Sr Reddy³

Affiliations

¹ Industrial Chemistry Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai, 600 020, India.
² Biomaterials & Drug Delivery Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, PO1 2DT, UK.
³ Industrial Chemistry Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai, 600 020, India. induchem2000@yahoo.com.

Abstract

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

Keywords: Captopril montmorillonite; Intercalation; Intestine-specific controlled release; Release kinetics.