Recent advances and progress in the detection of bisphenol A

Anal Bioanal Chem. 2016 Oct;408(25):6913-27. doi: 10.1007/s00216-016-9791-6. Epub 2016 Aug 2.

Abstract

Bisphenol A (BPA) is an important industrial chemical used as a plasticizer in polycarbonate and epoxy resins in the plastic and paper industries. Because of its estrogenic properties, BPA has attracted increasing attention from many researchers. This review focuses primarily on analytical methods for BPA detection that have emerged in recent years. We present and discuss the advantages and disadvantages of sample preparation techniques (e.g., solvent extraction, solid-phase extraction, molecularly imprinted polymer solid-phase extraction, and micro-extraction techniques) and analytical methods (e.g., liquid chromatography, liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, capillary electrophoresis, immunoassay, and several novel sensors). We also discuss expected future developments for the detection of BPA. Graphical Abstract This review focuses primarily on the recent development in the detection of bisphenol A including sample pre-treatment and analytical methods.

Keywords: Bisphenol A; Immunoassay; Mass spectrometry; Molecularly imprinted polymers; Sample pretreatment; Sensors.

Publication types

  • Review

MeSH terms

  • Animals
  • Aptamers, Nucleotide / chemistry
  • Benzhydryl Compounds / analysis*
  • Benzhydryl Compounds / isolation & purification
  • Biosensing Techniques / methods
  • Chemistry Techniques, Analytical / methods*
  • Chromatography, Affinity / methods
  • Chromatography, Liquid / methods
  • Electrophoresis, Capillary / methods
  • Endocrine Disruptors / analysis*
  • Endocrine Disruptors / isolation & purification
  • Environmental Pollutants / analysis*
  • Environmental Pollutants / isolation & purification
  • Enzyme-Linked Immunosorbent Assay / methods
  • Humans
  • Liquid-Liquid Extraction / methods
  • Mass Spectrometry / methods
  • Molecular Imprinting / methods
  • Phenols / analysis*
  • Phenols / isolation & purification
  • Plasticizers / analysis*
  • Plasticizers / isolation & purification
  • Polymers / chemistry
  • Solid Phase Extraction / methods

Substances

  • Aptamers, Nucleotide
  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Environmental Pollutants
  • Phenols
  • Plasticizers
  • Polymers
  • bisphenol A