Antimicrobial Agent Dosing in Infants

Abstract

Purpose: The goal of this article was to review infant physiology and its effects on the pharmacokinetic properties of antimicrobial agents.

Methods: A review of the drug development process was performed. A literature search was conducted on the pharmacokinetics of various antimicrobial agents in infants.

Findings: The pharmacokinetic properties of antimicrobial agents in infants are most often affected by the renal maturation of premature infants. Hepatic metabolism and volume of distribution play a common role as well.

Implications: The dosing and dosing intervals of various medications were reviewed and compared with details of adult dosing. It is vital to continue to gather pharmacokinetic data in infants to ensure adequate safety and dosing of medications.

Keywords: Antibiotics; antifungals; antivirals; infants; pharmacokinetics.