Targeting the fungal calcium-calcineurin signaling network in overcoming drug resistance

Future Med Chem. 2016 Aug;8(12):1379-81. doi: 10.4155/fmc-2016-0094. Epub 2016 Jul 27.

Authors

Xiuyun Li¹, Shujuan Sun²

Affiliations

¹ School of Pharmaceutical Sciences, Shandong University, Wenhuaxi Road, Jinan, 250012, China.
² Department of Pharmacy, Qianfoshan Hospital Affiliated to Shandong University, Jingshi Road, Jinan, 250014, China.

PMID: 27463738
DOI: 10.4155/fmc-2016-0094

No abstract available

Keywords: Crz1; Hph1/Hph2; Hsp90; Rta2; antifungal drug development; calcineurin; calcium channels; fungal resistance; potential drug targets.

Publication types

Editorial

MeSH terms

Antifungal Agents / pharmacology*
Antifungal Agents / therapeutic use
Calcineurin / metabolism*
Calcium Channels / metabolism*
Candida albicans / drug effects
Candida albicans / metabolism
Candidiasis / diagnosis
Candidiasis / drug therapy
Candidiasis / microbiology
Cyclosporins / chemistry
Cyclosporins / pharmacology
Cyclosporins / therapeutic use
Drug Resistance, Fungal / drug effects*
Fungal Proteins / metabolism*
HSP90 Heat-Shock Proteins / metabolism
Humans
Signal Transduction / drug effects*
Tacrolimus / pharmacology
Tacrolimus / therapeutic use

Substances

Antifungal Agents
Calcium Channels
Cyclosporins
Fungal Proteins
HSP90 Heat-Shock Proteins
Calcineurin
Tacrolimus