Objective: To examine the longitudinal association between dietary cholesterol intake and stroke incidence in Chinese adults.
Methods: The data were from 5833 non-stroke participants aged 30-98 in 1997 and more than one repeated measurements in the following five waves (2000, 2004, 2006, 2009 and 2011) of the China Health and Nutrition Survey. 5805 participants were included eventually after removing those with abnormal dietary cholesternul intake. Dietary cholesterol and energy intake was assessed with 3 d - 24 h dietary recalls in all the waves. Self-reported hypertension, diabetes mellitus, alcohol drinking, smoking, and standardized measurement of waist circumstance were collected also. Time-dependent Cox proportional hazard regression models were constructed to estimate relative risks (RR) with 95% confidence intervals (CI).
Results: During the mean 11. 3 years follow-up, 198 stroke events of 5805 participants were ascertained. The quintiles dietary cholesterol intake were 70.0, 146.9, 218.3, 297.8 and 425.9 mg/d. After adjusted for potential confounders, the time-dependent cholesterol intake, baseline cholesterol intake and the mean cholesterol intake during 1997-2011 were insignificantly associated with stroke. The relative risks and 95% confidence intervals were 1. 000 (0.999 - 1.001), 1.000 (0.999 - 1.001 ) and 0.999 (0.998 - 1.001) respectively. The cholesterol intake quintiles were insignificantly associated with stroke incidence. The relative risks and 95% confidence intervals versus lowest quintile were 0.812 (0.504 - 1.310), 0.644 (0.389 - 1.066) 0.913 (0.576 - 1.446) and 0.692 (0.416 - 1.152) respectively.
Conclusion: Effect of dietary cholesterol intake on stroke incidence might was insignificant in Chinese adults.