The formate bio-economy

Curr Opin Chem Biol. 2016 Dec:35:1-9. doi: 10.1016/j.cbpa.2016.07.005. Epub 2016 Jul 25.

Abstract

In this review we discuss the concept of the formate bio-economy: formate can be produced efficiently from various available resources and can be consumed by microbes as the sole carbon source for the production of value-added chemicals, directly addressing major challenges in energy storage and chemical production. We show that the formate assimilation pathways utilized by natural formatotrophs are either inefficient or are constrained to organisms that are difficult to cultivate and engineer. Instead, adapting model industrial organisms to formatotrophic growth using synthetic, specially tailored formate-assimilation routes could prove an advantageous strategy. Several studies have started to tackle this challenge, but a fully active synthetic pathway has yet to be established, leaving room for future undertakings.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Dioxide / metabolism
  • Formates / chemistry*
  • Formates / metabolism
  • Industrial Microbiology

Substances

  • Formates
  • Carbon Dioxide