Cu(I) complexes of bis(methyl)(thia/selena) salen ligands: Synthesis, characterization, redox behavior and DNA binding studies

Abstract

Mononuclear cuprous complexes 1 and 2, [{CH₃E(o-C₆H₄)CH=NCH₂}₂Cu]ClO₄; E=S/Se, have been synthesized by the reaction of bis(methyl)(thia/selena) salen ligands and [Cu(CH₃CN)₄]ClO₄. Both the products were characterized by elemental analysis, ESI-MS, FT-IR, ¹H/¹³C/⁷⁷Se NMR, and cyclic voltammetry. The complexes possess tetrahedral geometry around metal center with the N₂S₂/N₂Se₂ coordination core. Cyclic voltammograms of complexes 1 and 2 displayed reversible anodic waves at E_1/2=+0.08V and +0.10V, respectively, corresponding to the Cu(I)/Cu(II) redox couple. DNA binding studies of both the complexes were performed applying absorbance, fluorescence and molecular docking techniques. Competitive binding experiment of complexes with ct-DNA against ethidium bromide is performed to predict the mode of binding. The results indicate the groove binding mode of complexes 1 and 2 to DNA. The binding constants revealed the strong binding affinity of complexes towards ct-DNA.

Keywords: Cu(I) complexes; Cyclic voltammetry; DNA binding; Thia/selena-salen.