Abstract
Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2). In this proof-of-concept clinical study, we show that supplementation of SFN with broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure model. Therefore, dietary sulforaphane supplementation is not a promising candidate for larger scale clinical trials targeting airway inflammation.
Trial registration:
NCT01625130 . Registered 19 June, 2012.
Keywords:
Airway inflammation; Antioxidants; NRF2; Ozone; Sulforaphane.
Publication types
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Letter
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Adult
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / therapeutic use*
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Brassica / chemistry
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Cross-Over Studies
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Female
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Healthy Volunteers
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Humans
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Isothiocyanates / isolation & purification
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Isothiocyanates / therapeutic use*
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Leukocyte Disorders / chemically induced
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Leukocyte Disorders / immunology
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Leukocyte Disorders / metabolism
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Leukocyte Disorders / prevention & control*
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Lung / drug effects*
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Lung / immunology
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Lung / metabolism
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Male
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Middle Aged
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NF-E2-Related Factor 2 / agonists*
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NF-E2-Related Factor 2 / metabolism
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Neutrophil Infiltration / drug effects*
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Neutrophils / drug effects*
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Neutrophils / immunology
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Neutrophils / metabolism
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Ozone
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Phytotherapy
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Plants, Medicinal
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Pneumonia / chemically induced
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Pneumonia / immunology
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Pneumonia / metabolism
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Pneumonia / prevention & control*
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Sulfoxides
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Young Adult
Substances
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Anti-Inflammatory Agents
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Isothiocyanates
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NF-E2-Related Factor 2
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NFE2L2 protein, human
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Sulfoxides
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Ozone
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sulforaphane
Associated data
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ClinicalTrials.gov/NCT01625130