Two new flavones, aspergivones A (1) and B (2), were isolated from the fungus Aspergillus candidus cultured from the gorgonian coral Anthogorgia ochracea collected from the South China Sea. The structures of 1 and 2 were elucidated by NMR and MS methods and comparison with relatively known compounds. Only 2 showed slight inhibitory activity against alpha-glucosidase with an IC50 value of 244 μg/mL. Compounds 1 and 2 were also evaluated for their cytotoxic and antibacterial activities.
Keywords: Aspergillus candidus; alpha-glucosidase; flavone; gorgonian coral.