Unusual ocular presentations of ocular phaeohyphomycosis

Eye (Lond). 2016 Nov;30(11):1517-1519. doi: 10.1038/eye.2016.155. Epub 2016 Jul 22.

Abstract

PurposePhaeohyphomycosis are melanin-containing fungi that rarely infect the eye. We describe three cases of ocular infection with some unusual clinical features.MethodsSeries of three case reports describing three different presentations of phaeohyphomycosis of the eye, their histopathology, and management.ResultsCase 1 mimicked an inflamed conjunctival naevus and was excised on this basis, revealing a conjunctival retention cyst containing pigmented fungal hyphae. Case 2 showed a wooden foreign body incidentally associated with pigmented fungal hyphae, which required treatment with topical antifungal therapy. Case 3 clinically was thought to be a perforated uveal melanoma and comprised an extensive plaque of pigmented fungal hyphae over ulcerated cornea.ConclusionThe pigmented melanin containing hyphae of phaeohyphomycosis mimicked melanocytic lesions in two cases and was an incidental finding in the context of a surface foreign body.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Child
  • Conjunctival Diseases / diagnosis*
  • Conjunctival Diseases / drug therapy
  • Conjunctival Diseases / microbiology
  • Corneal Ulcer / diagnosis*
  • Corneal Ulcer / drug therapy
  • Corneal Ulcer / microbiology
  • Cysts / diagnosis*
  • Cysts / drug therapy
  • Cysts / microbiology
  • Diagnosis, Differential
  • Eye Foreign Bodies / diagnosis*
  • Eye Foreign Bodies / drug therapy
  • Eye Foreign Bodies / microbiology
  • Eye Infections, Fungal / diagnosis*
  • Eye Infections, Fungal / drug therapy
  • Eye Infections, Fungal / microbiology
  • Female
  • Granuloma, Foreign-Body / diagnosis*
  • Granuloma, Foreign-Body / drug therapy
  • Granuloma, Foreign-Body / microbiology
  • Humans
  • Male
  • Middle Aged
  • Phaeohyphomycosis / diagnosis*
  • Phaeohyphomycosis / drug therapy
  • Phaeohyphomycosis / microbiology
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Voriconazole