Abstract
Two topics that have attracted recent attention in the field of autophagy concern the source of the membrane that is used to form the autophagosome during macroautophagy and the role of noncanonical autophagic pathways. The 2 topics may converge when considering the intersection of autophagy with viral infection. We suggest that noncanonical autophagy, which is sensitive to treatment with brefeldin A, may converge with the infectious cycles of certain DNA and RNA viruses that utilize membrane from the ER and cis-Golgi.
Keywords:
Beclin 1; Ebola virus; autophagy; brefeldin A; coronavirus; herpesvirus.
Publication types
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Editorial
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Apoptosis Regulatory Proteins / metabolism
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Autophagy*
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Autophagy-Related Protein 5 / metabolism
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Autophagy-Related Protein 7 / metabolism
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Beclin-1 / metabolism
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Brefeldin A / chemistry*
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Brefeldin A / metabolism
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Cell Membrane / metabolism*
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Coronavirus
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Coronavirus Infections / metabolism
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Ebolavirus
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Endoplasmic Reticulum / metabolism
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Golgi Apparatus / metabolism
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Humans
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Microtubule-Associated Proteins / metabolism
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Virus Diseases / metabolism
Substances
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Apoptosis Regulatory Proteins
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Autophagy-Related Protein 5
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BECN1 protein, human
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Beclin-1
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Microtubule-Associated Proteins
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Brefeldin A
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Autophagy-Related Protein 7