Orthodontic needs to reply on a reliable anchoring as fixed as possible to ensure the best orthodontic movements. The orthodontic mini-screws provide a fixed anchorage for performing movements and treatments considered until then to be difficult or even impossible, particularly the treatment of ingression in the posterior area. The orthodontic anchorage mini-screw has the advantage of being cheaper, easier to place and do not require surgical procedure. This article illustrates two clinical indications of orthodontic mini-screws namely the intrusion of incisors and cross tooth movement.