Major Persistent 5' Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues

Emerg Infect Dis. 2016 Aug;22(8):1488-90. doi: 10.3201/eid2208.160186.

Abstract

We performed deep sequencing analysis of the enterovirus 5' noncoding region in cardiac biopsies from a patient with dilated cardiomyopathy. Results displayed a mix of deleted and full-length coxsackievirus B3, characterized by a low viral RNA load (8.10(2) copies/μg of nucleic acids) and a low viral RNA positive-sense to RNA negative-sense ratio of 4.8.

Keywords: 5′ terminally deleted populations; coxsackievirus B3; endomyocardial; enterovirus; heart; human; idiopathic dilated cardiomyopathy; viruses.

Publication types

  • Case Reports

MeSH terms

  • Coxsackievirus Infections / pathology
  • Coxsackievirus Infections / virology*
  • DNA Mutational Analysis
  • Endocarditis / virology*
  • Enterovirus B, Human / genetics*
  • Female
  • Heart / virology*
  • Humans
  • Middle Aged
  • Myocardium / pathology*
  • RNA, Viral
  • Sequence Deletion

Substances

  • RNA, Viral