Towards a DNA Nanoprocessor: Reusable Tile-Integrated DNA Circuits

Abstract

Modern electronic microprocessors use semiconductor logic gates organized on a silicon chip to enable efficient inter-gate communication. Here, arrays of communicating DNA logic gates integrated on a single DNA tile were designed and used to process nucleic acid inputs in a reusable format. Our results lay the foundation for the development of a DNA nanoprocessor, a small and biocompatible device capable of performing complex analyses of DNA and RNA inputs.

Keywords: DNA logic gates; NOR gates; crossover DNA tiles; molecular beacons; molecular computation.