Impact of CDT Toxin on Human Diseases

Toxins (Basel). 2016 Jul 15;8(7):220. doi: 10.3390/toxins8070220.

Abstract

Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects.

Keywords: CDT toxin; CDT-producing bacteria; DNA damage.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Proteins / metabolism*
  • Bacterial Toxins / metabolism*
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology
  • DNA Damage
  • Gram-Negative Bacteria / immunology
  • Gram-Negative Bacteria / metabolism
  • Gram-Negative Bacteria / pathogenicity*
  • Gram-Negative Bacterial Infections / immunology
  • Gram-Negative Bacterial Infections / metabolism
  • Gram-Negative Bacterial Infections / microbiology*
  • Gram-Negative Bacterial Infections / pathology
  • Host-Pathogen Interactions
  • Humans
  • Inflammation / immunology
  • Inflammation / metabolism
  • Inflammation / microbiology
  • Inflammation Mediators / immunology
  • Inflammation Mediators / metabolism
  • Neoplasms / metabolism
  • Neoplasms / microbiology
  • Neoplasms / pathology
  • Risk Factors

Substances

  • Bacterial Proteins
  • Bacterial Toxins
  • Inflammation Mediators
  • cytolethal distending toxin