First isolation of Candida wangnamkhiaoensis from the blood of immunocompromised paediatric patient

Mycoses. 2016 Nov;59(11):734-741. doi: 10.1111/myc.12509.

Abstract

Candida wangnamkhiaoensis is a species clustered under the Hyphopichia clade has not ever been isolated from any clinical specimens. To the best of our knowledge, this is the first report of C. wangnamkhiaoensis associated with fungaemia in immunocompromised paediatric patient. The isolate was assigned a strain name as UZ1679/14, in which the identification was confirmed by a polymerase chain reaction-sequencing of the internal transcribed spacer (ITS) and large subunit (LSU) regions of the rRNA gene. Antifungal susceptibility pattern showed that the isolate was sensitive to anidulafungin, caspofungin, fluconazole and voriconazole. The patient clinically improved after the antifungal treatment with caspofungin.

Keywords: Candida wangnamkhiaoensis; Hypopichia clade; fungaemia; immunocompromised patient.

Publication types

  • Case Reports

MeSH terms

  • Anidulafungin
  • Antifungal Agents / pharmacology
  • Candida / classification
  • Candida / genetics
  • Candida / isolation & purification*
  • Candida / ultrastructure
  • Candidemia / drug therapy
  • Candidemia / immunology
  • Candidemia / microbiology*
  • Caspofungin
  • Child, Preschool
  • DNA, Ribosomal Spacer
  • Echinocandins / pharmacology
  • Echinocandins / therapeutic use
  • Fluconazole / pharmacology
  • Humans
  • Hyphae / isolation & purification
  • Hyphae / ultrastructure
  • Immunocompromised Host*
  • Lipopeptides / pharmacology
  • Lipopeptides / therapeutic use
  • Male
  • Phylogeny
  • Polymerase Chain Reaction
  • Sequence Alignment
  • Voriconazole / pharmacology

Substances

  • Antifungal Agents
  • DNA, Ribosomal Spacer
  • Echinocandins
  • Lipopeptides
  • Fluconazole
  • Anidulafungin
  • Caspofungin
  • Voriconazole

Associated data

  • GENBANK/KP326581
  • GENBANK/KT362712
  • GENBANK/AB682911
  • GENBANK/AB682910