Triterpenoids from the fruit of Schisandra glaucescens

Abstract

Five new triterpenoids, named schiglausins P-T (1-5), together with twelve known analogues (6-17), were isolated from the fruit of Schisandra glaucescens Diels. Their structures were determined by various spectroscopic methods, including HRESIMS, 1D and 2D NMR spectra and CD experiment. Additionally, all these compounds were tested for their cytotoxicities against B16 mouse melanoma cell line. Compounds 8, 11, 14, and 15 exhibited moderate anti-proliferative effects against B16 cells with IC50 values ranging from 3.64 to 27.00μM.

Keywords: Cytotoxicity; Schisandra glaucescens Diels; Schisandraceae; Triterpenoids.