Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome

Jonathan B Shute; Michael S Okun; Enrico Opri; Rene Molina; P Justin Rossi; Daniel Martinez-Ramirez; Kelly D Foote; Aysegul Gunduz

doi:10.1016/j.nicl.2016.06.015

Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome

Neuroimage Clin. 2016 Jun 25:12:165-72. doi: 10.1016/j.nicl.2016.06.015. eCollection 2016.

Authors

Jonathan B Shute¹, Michael S Okun², Enrico Opri¹, Rene Molina³, P Justin Rossi⁴, Daniel Martinez-Ramirez⁵, Kelly D Foote⁶, Aysegul Gunduz⁷

Affiliations

¹ J. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32611, USA.
² Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32611, USA; Department of Neurology, University of Florida, Gainesville, FL 32611, USA; Department of Neurosurgery, University of Florida, Gainesville, FL 32611, USA.
³ J. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA.
⁴ Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32611, USA.
⁵ Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32611, USA; Department of Neurology, University of Florida, Gainesville, FL 32611, USA.
⁶ Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32611, USA; Department of Neurosurgery, University of Florida, Gainesville, FL 32611, USA.
⁷ J. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32611, USA; Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA.

Abstract

Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. Deep brain stimulation (DBS) is an emerging therapy for severe cases of TS. We studied two patients with TS implanted with bilateral Medtronic Activa PC + S DBS devices, capable of chronic recordings, with depth leads in the thalamic centromedian-parafascicular complex (CM-PF) and subdural strips over the precentral gyrus. Low-frequency (1-10 Hz) CM-PF activity was observed during tics, as well as modulations in beta rhythms over the motor cortex. Tics were divided into three categories: long complex, complex, and simple. Long complex tics, tics involving multiple body regions and lasting longer than 5 s, were concurrent with a highly detectable thalamocortical signature (average recall [sensitivity] 88.6%, average precision 96.3%). Complex tics were detected with an average recall of 63.9% and precision of 36.6% and simple tics an average recall of 39.3% and precision of 37.9%. The detections were determined using data from both patients.

Keywords: Centromedian thalamus; Deep brain stimulation; Motor cortex; Tourette syndrome.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural

MeSH terms

Adult
Beta Rhythm
Deep Brain Stimulation
Female
Humans
Intralaminar Thalamic Nuclei / physiopathology*
Motor Cortex / physiopathology*
Neural Pathways / physiopathology
Tics / diagnosis
Tics / etiology
Tics / physiopathology*
Tourette Syndrome / complications
Tourette Syndrome / diagnosis
Tourette Syndrome / physiopathology*
Young Adult

Abstract

Publication types

MeSH terms

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