A potential role for estrogen in cigarette smoke-induced microRNA alterations and lung cancer

Amit Cohen; Mario Alberto Burgos-Aceves; Yoav Smith

doi:10.21037/tlcr.2016.06.08

A potential role for estrogen in cigarette smoke-induced microRNA alterations and lung cancer

Transl Lung Cancer Res. 2016 Jun;5(3):322-30. doi: 10.21037/tlcr.2016.06.08.

Authors

Amit Cohen¹, Mario Alberto Burgos-Aceves¹, Yoav Smith¹

Affiliation

¹ 1 Genomic Data Analysis Unit, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel ; 2 Centro de Investigaciones Biológicas de Noroeste, S.C., Mar Bermejo 195, Col. Playa Palo de Sta, Rita, La Paz, BCS, México.

Abstract

Alteration in the expression of microRNAs (miRNAs) is associated with oncogenesis and cancer progression. In this review we aim to suggest that elevated levels of estrogens and their metabolites inside the lungs as a result of cigarette smoke exposure can cause widespread repression of miRNA and contribute to lung tumor development. Anti-estrogenic compounds, such as the components of cruciferous vegetables, can attenuate this effect and potentially reduce the risk of lung cancer (LC) among smokers.

Keywords: Cigarette-smoke (CS); estrogen; lung cancer (LC); microRNA (miRNA).

Publication types

Review