Nicolai Kravkov's pancreotoxine

J Med Biogr. 2018 Aug;26(3):189-193. doi: 10.1177/0967772015611789. Epub 2016 Jul 13.

Abstract

The article reviews the life and work of an outstanding Russian pharmacologist Professor Nikolai Kravkov (1865-1924). Among his many scientific achievements, he worked on an extract from the pancreas of animals in the early 1920s and was successful in isolating the internal secretion, which he named "pancreotoxine." This reduced blood glucose levels in animals and diabetic humans. Kravkov's work on the isolation of pancreotoxine was going on coincidentally with F. Banting's and C. Best's research of insulin, but their methods of isolation of the hormone were quite different.

Keywords: Military Medical Academy; Nikolai Kravkov; Russian pharmacology; pancreotoxine (insulin).

Publication types

  • Biography
  • Historical Article
  • Portrait

MeSH terms

  • Animals
  • Blood Glucose / drug effects
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / history*
  • Diabetes Mellitus / prevention & control
  • History, 19th Century
  • History, 20th Century
  • Humans
  • Pancreatic Extracts / history*
  • Pancreatic Extracts / isolation & purification
  • Pharmacology / history*
  • Russia

Substances

  • Blood Glucose
  • Pancreatic Extracts

Personal name as subject

  • Nicolai Kravkov