A case of intraparotid schwannoma in a juvenile: Clinical, pathological, ultrastructural, and immunohistopathological study, including an examination of Ki-67 and MCM-3 expressions

Ultrastruct Pathol. 2016 Jul-Aug;40(4):222-8. doi: 10.1080/01913123.2016.1192234. Epub 2016 Jul 13.

Abstract

Pleomorphic adenoma, the most common benign nonvascular tumor of the parotid gland in juveniles, should be differentiated from other extremely rare tumors, including schwannoma. In this article, we present a rare case of an intraparotid schwannoma in a juvenile, along with the patient history, a description of pathological features, and the results of ultrastructural and immunohistochemical examination. The respective labeling indexes of Ki-67 and MCM-3, i.e., the mean proportions of positive tumor cells out of 1000 tumoral cells counted in 10 microscopic fields at ×400 magnification, given as a percentage, were found to be 0.82% and 0.4%, respectively.

Keywords: Intraparotid; Ki-67; MCM-3; juvenile; schwannoma.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Biomarkers, Tumor / analysis
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen / analysis
  • Ki-67 Antigen / biosynthesis
  • Male
  • Microscopy, Electron, Transmission
  • Minichromosome Maintenance Complex Component 3 / analysis
  • Minichromosome Maintenance Complex Component 3 / biosynthesis
  • Neurilemmoma / diagnosis*
  • Neurilemmoma / pathology
  • Neurilemmoma / ultrastructure
  • Parotid Neoplasms / diagnosis*
  • Parotid Neoplasms / pathology
  • Parotid Neoplasms / ultrastructure

Substances

  • Biomarkers, Tumor
  • Ki-67 Antigen
  • MCM3 protein, human
  • Minichromosome Maintenance Complex Component 3