Family-based association study of interleukin 10 (IL10) and interleukin 10 receptor alpha (IL10RA) functional polymorphisms in schizophrenia in Polish population

J Neuroimmunol. 2016 Aug 15:297:92-7. doi: 10.1016/j.jneuroim.2016.05.010. Epub 2016 May 13.

Abstract

Schizophrenia is a heterogeneous disorder and its etiology remains incompletely elucidated. Among possible causes, immunological factors have been implicated in its pathogenesis and course. Interleukin-10 (IL10) and it's receptor IL10RA may play an important role for immunological aspects in etiologies of major psychiatric disorders including schizophrenia. The aim of this study was to perform a transmission disequilibrium test (TDT) on a group of 146 schizophrenia trios from the Polish population. Functional polymorphisms from IL10 (rs1800872, rs1800871, rs1800896, rs1800890, and rs6676671) and IL10RA (rs3135932 and rs2229113) genes were analyzed. A lack of association with schizophrenia was detected for IL10 and IL10RA single polymorphisms and haplotypes.

Keywords: Interleukin 10 (IL10); Interleukin 10 receptor alpha (IL10RA); Polymorphism; Schizophrenia; Transmission disequilibrium test (TDT).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Family Health
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Interleukin-10 / genetics*
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Poland
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, Interleukin-10 / genetics*
  • Schizophrenia / genetics*
  • Young Adult

Substances

  • Receptors, Interleukin-10
  • Interleukin-10