Surfactant-Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging

Yumiao Zhang; Depeng Wang; Shreya Goel; Boyang Sun; Upendra Chitgupi; Jumin Geng; Haiyan Sun; Todd E Barnhart; Weibo Cai; Jun Xia; Jonathan F Lovell

doi:10.1002/adma.201602373

Surfactant-Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging

Adv Mater. 2016 Oct;28(38):8524-8530. doi: 10.1002/adma.201602373. Epub 2016 Jul 11.

Authors

Yumiao Zhang^{1

2}, Depeng Wang¹, Shreya Goel³, Boyang Sun², Upendra Chitgupi¹, Jumin Geng¹, Haiyan Sun⁴, Todd E Barnhart⁵, Weibo Cai^{4

5}, Jun Xia¹, Jonathan F Lovell^{6

7}

Affiliations

¹ Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
² Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
³ Materials Science Program, University of Wisconsin-Madison, Madison, WI, 53705, USA.
⁴ Department of Radiology, University of Wisconsin-Madison, Madison, WI, 53705, USA.
⁵ Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.
⁶ Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. jflovell@buffalo.edu.
⁷ Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. jflovell@buffalo.edu.

Abstract

Edible, surfactant-stripped, frozen micelles are formed from pheophytin (demetallated chlorophyll), a pigment that is naturally consumed in human diets. Pheophytin nanoparticles pass completely and safely through the gastrointestinal tract and enable trimodal gut contrast imaging via photoacoustic, fluorescence, and positron emission tomography techniques.

Keywords: chlorophyll; frozen micelles; gut imaging; multimodal imaging; pheophytin.

MeSH terms

Animals
Chlorophyll
Female
Intestines
Mice
Mice, Inbred ICR
Micelles
Multimodal Imaging
Pheophytins / chemistry*
Surface-Active Agents

Substances

Micelles
Pheophytins
Surface-Active Agents
Chlorophyll

Abstract

MeSH terms

Substances

Grants and funding